A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins

Am J Hypertens. 2003 Feb;16(2):158-62. doi: 10.1016/s0895-7061(02)03245-4.

Abstract

Background: Our understanding of genes that predispose to essential hypertension is poor.

Methods: A genome-wide scan for linkage at approximately 10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low-normal blood pressure (BP) (N = 184), or discordant for BP (N = 580).

Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5.

Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Asian People*
  • China / ethnology
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 10
  • Genetic Predisposition to Disease / genetics*
  • Genome, Human*
  • Humans
  • Hypertension / genetics*
  • Japan / ethnology
  • Lod Score
  • Middle Aged