Abstract
A new naphthylisoquinoline alkaloid, ancistrolikokine D, and the likewise 5,8'-coupled alkaloid ancistroealaine A, as well as two further, biosynthetically related, but nitrogen-free natural products, ancistronaphthoic acid B and cis-isoshinanolone, have been isolated from Ancistrocladus likoko J. LEACUTE;ONARD (Ancistrocladaceae). The 5,8'-coupling of the new alkaloids and of the alkaloids isolated earlier hints at a close phylogenetic relationship of A. likoko to other Central African Ancistrocladus species. The compounds show moderate activities against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei rhodesiense.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Caryophyllaceae / chemistry*
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Cell Line
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Cell Survival / drug effects
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Democratic Republic of the Congo
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Inhibitory Concentration 50
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Isoquinolines / chemistry*
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Isoquinolines / isolation & purification*
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Isoquinolines / pharmacology
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Leishmania donovani / drug effects
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Naphthalenes / chemistry*
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Naphthols / chemistry
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Naphthols / isolation & purification*
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Naphthols / pharmacology
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Plant Roots / chemistry
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Plasmodium falciparum / drug effects
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Rats
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Structure-Activity Relationship
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Trypanosoma / drug effects
Substances
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Alkaloids
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Anti-Infective Agents
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Biological Products
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Isoquinolines
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Naphthalenes
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Naphthols
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ancistrolikokine D