Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies

J Clin Pathol. 2003 Feb;56(2):91-5. doi: 10.1136/jcp.56.2.91.

Abstract

The classification and grading of the non-invasive, intraepithelial neoplasms of the urothelium are based on the morphological pattern of growth-that is, papillary or flat (and endophytic)-and on their degree of architectural and cytological abnormalities. Recent advances in the morphological, molecular, and quantitative evaluation of these lesions have contributed to the refinement of the current classification and grading schemes. However, some controversies on the precise criteria and terminology, especially when the papillary lesions are concerned, are still present.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinoma in Situ / classification
  • Carcinoma in Situ / genetics
  • Carcinoma in Situ / pathology*
  • Carcinoma, Transitional Cell / classification
  • Carcinoma, Transitional Cell / genetics
  • Carcinoma, Transitional Cell / pathology*
  • Chromosomes, Human, Pair 9
  • Humans
  • Loss of Heterozygosity
  • Terminology as Topic
  • Urinary Bladder Neoplasms / classification
  • Urinary Bladder Neoplasms / genetics
  • Urinary Bladder Neoplasms / pathology*