Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-A(b-/-) mice

J Gen Virol. 2003 Feb;84(Pt 2):337-341. doi: 10.1099/vir.0.18821-0.

Abstract

The murine gammaherpesvirus-68 kills I-A(b-/-) mice despite the presence of virus-specific CD8+ cytotoxic T lymphocytes (CTL). This has raised the possibility that these CTL are functionally abnormal. Here, no difference was observed between I-A(b-/-) mice and I-A(b+/+) controls in virus-specific CTL function, T cell receptor usage, or surface phenotype. Thus CTL immunity was independent of CD4+ T cells in a chronic herpesvirus infection, but was still inadequate to control virus replication.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • Gammaherpesvirinae / pathogenicity*
  • H-2 Antigens / metabolism
  • Herpesviridae Infections / immunology*
  • Herpesviridae Infections / virology
  • Histocompatibility Antigen H-2D
  • Mice
  • Peptide Fragments / metabolism
  • Receptors, Antigen, T-Cell, alpha-beta / metabolism
  • T-Lymphocytes, Cytotoxic / immunology*

Substances

  • H-2 Antigens
  • H-2K(K) antigen
  • Histocompatibility Antigen H-2D
  • Peptide Fragments
  • Receptors, Antigen, T-Cell, alpha-beta