Abstract
Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric volume were only observed at the highest dose of the drug. In another set of experiments, when 50% alcohol (v/v) was administered to the pyloric-ligated rats pretreated with amitriptyline, it was observed that the drug significantly reduced the pH, total acidity and protein content.
MeSH terms
-
Amitriptyline / pharmacology
-
Amitriptyline / therapeutic use*
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / adverse effects
-
Antidepressive Agents / pharmacology
-
Antidepressive Agents / therapeutic use*
-
Aspirin / adverse effects
-
Cold Temperature / adverse effects
-
Ethanol / adverse effects
-
Gastric Acid / metabolism
-
In Vitro Techniques
-
Indomethacin / adverse effects
-
Male
-
Models, Biological
-
Muscarinic Antagonists / pharmacology
-
Muscarinic Antagonists / therapeutic use*
-
Rats
-
Stomach Ulcer / etiology
-
Stomach Ulcer / pathology
-
Stomach Ulcer / prevention & control*
-
Stress, Psychological / complications
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antidepressive Agents
-
Muscarinic Antagonists
-
Amitriptyline
-
Ethanol
-
Aspirin
-
Indomethacin