The macroscopic anatomical study of 27 cases of patients aged over 75 years did not show any significant difference between the myocardial and established coronary artery lesions, and those of a numericaly related group of young subjects. These anatomical facts are inducive to take more into account the physiological age of patients, and not to statistically exclude certain old patients from the eventual benefit of therapy and full investigation, at present reserved for younger patients.