Abstract
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we aim to provide a brief summary of (1) our understanding of the roles of these enzymes in pancreatic cancer tumorigenesis and progression; and (2) the potential of using cyclooxygenase and lipoxygenase inhibitors for pancreatic cancer treatment and prevention.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Cyclooxygenase Inhibitors / therapeutic use
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Humans
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Lipoxygenase / metabolism*
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Lipoxygenase Inhibitors / therapeutic use
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Neoplasm Invasiveness / prevention & control
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Neovascularization, Pathologic / prevention & control
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Pancreatic Neoplasms / drug therapy*
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Pancreatic Neoplasms / enzymology
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Pancreatic Neoplasms / prevention & control
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Prostaglandin-Endoperoxide Synthases / metabolism*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase Inhibitors
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Lipoxygenase Inhibitors
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Lipoxygenase
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Prostaglandin-Endoperoxide Synthases