Novel channel structure of bile acid-guest inclusion complex formed between ursodeoxycholic acid and phenanthrene

Chem Pharm Bull (Tokyo). 2003 Feb;51(2):227-9. doi: 10.1248/cpb.51.227.

Abstract

The crystal structure of inclusion complex between ursodeoxycholic acid (UDCA), and phenanthrene has been determined. UDCA molecules formed hydrogen bond network to provide the channel structure along b axis, and phenanthrene molecules were accommodated in the cavity with a stoichiometry of 1 : 1 molar ratio. The channel structure observed in the UDCA-phenanthrene complex was significantly different from that of inclusion complex previously reported for deoxycholic acid (DCA) and cholic acid (CA). Because of the mesh-like hydrogen bond network, channel framework of UDCA could have less flexibility than that of DCA and CA. The difference of molecular state of phenanthrene was clearly observed in solid-state fluorescence measurement.

MeSH terms

  • Bile Acids and Salts / chemistry*
  • Molecular Structure
  • Phenanthrenes / chemistry*
  • Ursodeoxycholic Acid / chemistry*

Substances

  • Bile Acids and Salts
  • Phenanthrenes
  • phenanthrene
  • Ursodeoxycholic Acid