Abstract
DNA is a dynamic molecule that undergoes constant changes in the cell through interactions with numerous proteins. Several classes of enzyme are specialized in promoting DNA rearrangements, including site-specific recombinases, DNA helicases, transposases and DNA topoisomerases. Recent structures of protein-DNA reaction intermediates trapped in various states of DNA remodeling, complemented by biochemical and biophysical functional studies, have enhanced our understanding of their respective mechanistic pathways.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Binding Sites
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Catalysis
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DNA / chemistry*
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DNA / metabolism*
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DNA Helicases / chemistry
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DNA Helicases / metabolism
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DNA Nucleotidyltransferases / chemistry
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DNA Nucleotidyltransferases / metabolism
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DNA Topoisomerases / chemistry
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DNA Topoisomerases / metabolism
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DNA Topoisomerases, Type I / chemistry
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DNA Topoisomerases, Type I / metabolism
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Integrases / chemistry*
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Integrases / metabolism
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Isomerases / chemistry*
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Isomerases / metabolism
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Macromolecular Substances
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Models, Molecular*
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Nucleic Acid Conformation
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Protein Binding
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Protein Conformation
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Recombinases
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Recombination, Genetic
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Transposases / chemistry
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Transposases / metabolism
Substances
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Macromolecular Substances
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Recombinases
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DNA
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DNA Nucleotidyltransferases
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Integrases
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Transposases
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DNA Helicases
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Isomerases
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DNA Topoisomerases
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DNA reverse gyrase
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DNA Topoisomerases, Type I