Objective: To observe the effect of Changtong Oral Liquid (CTOL) on the fibrinolytic activity of rabbits with experimental intestinal adhesion.
Methods: Intestinal adhesion model of rabbits were made with reference to that described by Thomas and Rhoads and the animals were continuously orally supplemented with CTOL for seven days. Changes of tissue plasminogen activator (t-pA) and plasminogen activator inhibitor activity (PAI) as well as the intestinal adhesion were investigated.
Results: Different dosage of CTOL produced protective effects on the postoperative intestinal adhesion accompanied by significant enhancement of t-PA activity and pronounced decreasement of PAI activity.
Conclusion: CTOL maybe play protective role in postoperative intestinal adhesion by modulating the activity of fibrinolytic system.