Mono- versus bidentate ligands in rhodium-catalyzed asymmetric hydrogenation. A comparative rate study

Org Lett. 2003 Feb 20;5(4):475-8. doi: 10.1021/ol027457t.

Abstract

[reaction: see text] Bidentate chiral phosphines are no longer essential for achieving a fast and highly enantioselective hydrogenation of alpha- or beta-dehydroamino acid derivatives. In particular, a readily accessible and stable monodentate phosphoramidite can be highly effective in these asymmetric hydrogenations.