[Study on preventive effect of jiangu granule on osteoporosis in ovariectomized rats]

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2002 May;22(5):369-71.
[Article in Chinese]

Abstract

Objective: To investigate the preventive effect of Jiangu granule (JGG) on experimental primary osteoporosis type I.

Methods: Osteoporosis model was established through ovary resection of female rats. Bone mineral density (BMD) was measured with double energy X-ray absorptiometry. Level of endocrine markers, including osteocalcin (BGP), estradiol (E2) and calcitonin (CT) in serum were examined by RIA. And uterus parameters was calculated also.

Results: JGG could significantly increase BMD and uterus index, improve the levels of E2 and CT in serum, at the same time reduce the BGP level.

Conclusion: JGG can efficiently prevent type I primary osteoporosis or delay its occurrence by enhancing the function of endocrine system, coordinating the action of calcium related hormone, reducing bone turnover rate and increasing BMD.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Density
  • Calcitonin / blood
  • Drugs, Chinese Herbal / pharmacology*
  • Estradiol / blood
  • Female
  • Osteocalcin / blood*
  • Osteoporosis / blood
  • Osteoporosis / prevention & control*
  • Ovariectomy
  • Phytotherapy*
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Drugs, Chinese Herbal
  • Osteocalcin
  • Estradiol
  • Calcitonin