The synthesis of a single enantiomer of a major alpha-mycolic acid of Mycobacterium tuberculosis

Chem Commun (Camb). 2003 Jan 21:(2):228-9. doi: 10.1039/b209876h.

Abstract

We report a synthesis of a single enantiomer of a dicyclopropane containing mycolic acid from Mycobacterium tuberculosis; this method can be simply varied to modify the chain lengths or the absolute stereochemistry of either cyclopropane.

MeSH terms

  • Cyclopropanes
  • Molecular Structure
  • Mycobacterium tuberculosis / chemistry*
  • Mycolic Acids / chemical synthesis*
  • Mycolic Acids / chemistry
  • Stereoisomerism

Substances

  • Cyclopropanes
  • Mycolic Acids