Correlation between structure, aggregation behaviour and cellular toxicity of anti-HIV catanionic analogues of galactosylceramide

Muriel Blanzat; Emile Perez; Isabelle Rico-Lattes; Armand Lattesa; Annette Gulik

doi:10.1039/b210392n

Correlation between structure, aggregation behaviour and cellular toxicity of anti-HIV catanionic analogues of galactosylceramide

Chem Commun (Camb). 2003 Jan 21:(2):244-5. doi: 10.1039/b210392n.

Authors

Muriel Blanzat¹, Emile Perez, Isabelle Rico-Lattes, Armand Lattesa, Annette Gulik

Affiliation

¹ Laboratoire des Interactions Moléculaire et Réactivité Chimique et Photochimique, CNRS UMR 5623, Université P. Sabatier, 118 route de Narbonne, 31062 Toulouse cedex, France. [email protected]

PMID: 12585412
DOI: 10.1039/b210392n

Abstract

The self-association process of catanionic analogues of galactosylceramide and in particular the arrangement of their hydrophobic part seems to play a key role in their cellular toxicity

MeSH terms

Anti-HIV Agents / chemistry*
Anti-HIV Agents / pharmacology
Anti-HIV Agents / toxicity
Cell Survival / drug effects*
Dimerization
Galactosylceramides / chemical synthesis*
Galactosylceramides / pharmacology
Galactosylceramides / toxicity
Humans
Hydrophobic and Hydrophilic Interactions
Molecular Structure
Structure-Activity Relationship

Substances

Anti-HIV Agents
Galactosylceramides