Prior time-course investigations of cerebral asymmetries in word processing have sometimes reported hemisphere differences in the onset and duration of semantic priming. In the current study, very strongly related word pairs (categorical associates such as arm-leg) were employed in a low relatedness proportion lexical decision priming paradigm. A range of prime-target stimulus onset asynchronies (SOAs: 150-800 ms) was included. Only very weak evidence was obtained for a LVF priming lag at the briefest SOA, while priming was bilateral at moderately long SOAs. We consider these data in the context of previous time-course studies and suggest that, when highly semantically similar word pairs are used, a right hemisphere priming lag is, at best, a very small effect.