Abstract
Previous studies revealed that cholinergic neurons possessing long axons are extremely sensitive to ethylcholine aziridinium ion (AF64A) administration [Neuropharmacology 31 (1992) 397]. In the present paper we examined the effect of AF64A on the cholinergic elements of the cingulum bundle. Seven days after AF64A administration choline acetyltransferase (ChAT)-immunoreactive fibers were extensively damaged on the dorsal part of cingulum bundle. These findings are the first reporting damage by AF64A to this brain region.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Aziridines / pharmacology*
-
Choline / analogs & derivatives*
-
Choline / pharmacology*
-
Choline O-Acetyltransferase / analysis*
-
Cholinergic Fibers / chemistry
-
Cholinergic Fibers / drug effects*
-
Dose-Response Relationship, Drug
-
Gyrus Cinguli / chemistry
-
Gyrus Cinguli / drug effects*
-
Male
-
Rats
-
Rats, Inbred F344
-
Toxins, Biological / pharmacology*
Substances
-
Aziridines
-
Toxins, Biological
-
ethylcholine aziridinium
-
Choline O-Acetyltransferase
-
Choline