Synthesis of aza mono, bi and tricyclic compounds. Evaluation of their anti MDR activity

Eur J Med Chem. 2003 Jan;38(1):19-26. doi: 10.1016/s0223-5234(02)01422-8.

Abstract

Anti MDR activity of a series of acridine, pyridoquinoline, quinoline and pyridine analogous amines was evaluated. Interesting activity is displayed by tricyclic compounds. Besides ring size, influence of the side chain was studied.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / chemistry
  • Acridines / chemical synthesis*
  • Acridines / pharmacology
  • Animals
  • Aza Compounds / chemical synthesis*
  • Aza Compounds / pharmacology*
  • Cell Line, Tumor / drug effects
  • Drug Resistance, Multiple / drug effects*
  • Fluorescent Dyes
  • Leukemia L5178
  • Mice
  • Models, Chemical
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology
  • Quinolines / chemical synthesis*
  • Quinolines / pharmacology
  • Rhodamine 123
  • Structure-Activity Relationship

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Acridines
  • Aza Compounds
  • Fluorescent Dyes
  • Pyridines
  • Quinolines
  • Rhodamine 123