Abstract
In this study, we investigated the role of interleukin-6 (IL-6) in Giardia lamblia infections in mice. Elevated IL-6 expression was found in wild-type mice 15 days postinfection. Furthermore, IL-6-deficient mice controlled infections only slowly although normal immunoglobulin A production was observed. Thus, IL-6 is necessary for early control of acute G. lamblia infections.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acute Disease
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Animals
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Antibodies, Protozoan / biosynthesis
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Chronic Disease
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Giardia lamblia / immunology
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Giardiasis / immunology*
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Immunoglobulin A / biosynthesis
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Interleukin-6 / genetics
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Interleukin-6 / physiology*
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Mice
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Mice, Inbred C57BL
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RNA, Messenger / analysis
Substances
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Antibodies, Protozoan
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Immunoglobulin A
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Interleukin-6
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RNA, Messenger