Abstract
An outbreak of 7 cases of group C meningococcal disease occurred during the last week of July and the first week of August 2001 in the southwestern part of The Netherlands. Characterization of the 7 patients' isolates by various typing methods showed that the isolates were identical, except for the expression of PorA. Isolates from 5 patients were PorA deficient. These results show that transmission of PorA-deficient meningococci occurs and that PorA-deficient meningococci can cause invasive disease. PorA-based meningococcal vaccines may provide limited protection.
MeSH terms
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Adolescent
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Adult
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Bacterial Typing Techniques
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Child
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Child, Preschool
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Disease Outbreaks*
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Female
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Humans
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Male
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Meningococcal Infections / epidemiology*
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Meningococcal Infections / microbiology*
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Molecular Sequence Data
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Neisseria meningitidis, Serogroup C / classification*
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Neisseria meningitidis, Serogroup C / genetics
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Neisseria meningitidis, Serogroup C / isolation & purification
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Netherlands / epidemiology
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Porins / genetics
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Porins / metabolism*
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Sequence Analysis, DNA
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Serotyping
Substances
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Porins
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porin protein, Neisseria
Associated data
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GENBANK/AY166656
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GENBANK/AY166657