Abstract
Salmonella Typhimurium DT12, isolated from a 35-day-old infant with diarrhea, was highly resistant to ampicillin, tetracycline, chloramphenicol, streptomycin, gentamycin, sulfamethoxazole/trimethoprim, nalidixic acid, and fluoroquinolones. The patient responded to antibiotic therapy with fosfomycin. Multidrug-resistance may become prevalent in Salmonella infections in Japan, as shown in this first case of a patient infected with fluoroquinolone-resistant Salmonella.
MeSH terms
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Anti-Infective Agents / pharmacology*
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DNA Gyrase / genetics
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DNA Topoisomerase IV / genetics
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Diarrhea, Infantile / drug therapy
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Diarrhea, Infantile / microbiology*
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Drug Resistance, Multiple, Bacterial
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Fluoroquinolones
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Fosfomycin / administration & dosage
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Fosfomycin / pharmacology
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Genes, Bacterial*
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Humans
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Infant
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Male
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Mutation*
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Salmonella Food Poisoning / pathology
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Salmonella Infections / drug therapy
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Salmonella Infections / microbiology*
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics*
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Salmonella typhimurium / isolation & purification
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Fosfomycin
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DNA Topoisomerase IV
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DNA Gyrase