Genetics of alcoholism using intermediate phenotypes

Alcohol Clin Exp Res. 2003 Feb;27(2):169-76. doi: 10.1097/01.ALC.0000052702.77807.8C.

Abstract

This article represents the proceedings of a symposium at the 2002 meeting of the Research Society on Alcoholism in San Francisco, CA. It was organized by Mary-Anne Enoch and David Goldman and chaired by David Goldman. The presentations were (1) Two functional polymorphisms and their intermediate phenotypes in complex behaviors: COMT/executive cognition and anxiety and HTT/anxiety, by David Goldman; (2) Role of the EEG in determining genetic risk for alcoholism and anxiety disorders, by Mary-Anne Enoch; (3) The response to alcohol as an intermediate phenotype for alcoholism, by Marc A. Schuckit; and (4) Pharmacogenomic approaches to alcoholism treatment: toward a hypothesis, by Bankole A. Johnson.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alcohol Drinking / genetics
  • Alcoholism / genetics*
  • Alcoholism / physiopathology
  • Animals
  • Anxiety Disorders / genetics
  • Anxiety Disorders / physiopathology
  • Carrier Proteins / genetics
  • Catechol O-Methyltransferase / genetics
  • Chromosome Mapping
  • Gene Expression Regulation / physiology
  • Humans
  • Membrane Glycoproteins / genetics
  • Membrane Transport Proteins*
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins*
  • Phenotype*
  • Polymorphism, Genetic / genetics
  • Promoter Regions, Genetic / genetics
  • Serotonin Plasma Membrane Transport Proteins

Substances

  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Slc6a4 protein, mouse
  • Catechol O-Methyltransferase