Abstract
Both membranous glomerulopathy and acute interstitial nephritis have been reported to occur following treatment with non-steroidal anti-inflammatory drugs. We report the first cases of membranous glomerulopathy and acute interstitial nephritis following treatment with celecoxib (Celebrex), a selective COX-2 inhibitor. The rapid and complete resolution of both conditions following discontinuation of Celebrex strongly implicates this agent in disease pathogenesis. These cases enlarge the spectrum of potential renal toxicities of the COX-2-specific non-steroidal anti-inflammatory drugs.
MeSH terms
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Acute Disease
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Aged
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Arthritis, Rheumatoid / drug therapy
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Celecoxib
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Female
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Follow-Up Studies
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Glomerulonephritis, Membranous / chemically induced*
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Glomerulonephritis, Membranous / drug therapy
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Glucocorticoids / therapeutic use
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Humans
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Kidney / pathology*
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Male
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Nephritis, Interstitial / chemically induced*
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Nephritis, Interstitial / drug therapy
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Osteoarthritis / drug therapy
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Prednisone / therapeutic use
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Pyrazoles
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Sulfonamides / adverse effects*
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Sulfonamides / therapeutic use
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Glucocorticoids
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Pyrazoles
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Sulfonamides
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Celecoxib
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Prednisone