Abstract
Chemical investigation of the Micronesian ascidian Eudistoma sp. afforded two new eudistomin congeners, which were designated eudistomins W (1) and X (2). The structures of the new compounds were unambiguously established on the basis of NMR spectroscopic ((1)H, (13)C, COSY, (1)H detected direct, and long-range (13)C-(1)H correlations) and mass spectrometric (EI and ESIMS) data. Compound 2 exhibited antibiotic activity toward Bacillus subtilis, Staphyloccocus aureus, and Escherichia coli and was also found to be fungicidal against Candida albicans in an agar diffusion assay. Compound 1 was selectively active against C. albicans but showed no antibacterial activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Bacillus subtilis / drug effects
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Candida albicans / drug effects
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Carbolines / chemistry
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Carbolines / isolation & purification*
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Carbolines / pharmacology
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Escherichia coli / drug effects
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Micronesia
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Spectrometry, Mass, Electrospray Ionization
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Staphylococcus aureus / drug effects
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Urochordata / chemistry*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Carbolines
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eudistomin W
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eudistomin X