Abstract
Cancer cell line bioassay-guided separation of an extract from a Yukon Territory fungus resulted in the isolation of a new C(16)-terpene dilactone designated yukonin (1) accompanied by two previously known, structurally related constituents (2 and 3). The structure of each was determined by X-ray crystallographic analysis. Dilactone 2 was found to correspond to LL-Z1271alpha isolated from fungi in the genera Oidiodendron, Acrostalagmus, and Holwaya, while dilactone 3 had earlier been prepared by reduction of an alpha-lactol derivative. Each of the dilactones was found to inhibit growth of human cancer cell lines (pancreas, breast, CNS, lung, colon, and prostate) and some pathogenic fungi.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Molecular Conformation
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Molecular Structure
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Phialophora / chemistry*
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Plants, Medicinal / chemistry*
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Terpenes / chemistry
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Terpenes / isolation & purification*
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Terpenes / pharmacology
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Tumor Cells, Cultured / drug effects
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Yukon Territory
Substances
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Antineoplastic Agents
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Lactones
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Terpenes
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yukonin