Abstract
In addition to the known junceelolide C (4), three new briaranes, juncenolides B (1), C (2), and D (3), have been isolated from the acetone extract of a red Gorgonian Junceella juncea collected in Taiwan. The structures of 1-3 were elucidated on the basis of FABMS and 2D NMR techniques including COSY, HMQC, HMBC, and NOESY experiments. Among them, compound 2 exhibited mild cytotoxicity against human liver carcinoma (HEPA 59T/VGH) and oral epidermoid (KB) carcinoma cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cnidaria / chemistry*
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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Indian Ocean
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KB Cells / drug effects
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / pharmacology
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Liver Neoplasms
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Taiwan
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Tumor Cells, Cultured / drug effects
Substances
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Diterpenes
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Lactones
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junceelolide C