Abstract
A new triterpenoid saponin, loniceroside C was isolated from the aerial parts of Lonicera japonica. Its structure was established to be 3-O-beta-D-glucopyranosyl hederagenin 28-O-alpha-L-rhamnopyranosyl (1-->2)-[beta-D-xylopyranosyl(1-->6)]-beta-D-glucopyranosyl ester by spectroscopic techniques and chemical transformations. Loniceroside C showed in vivo antiinflammatory activity against mouse ear edema provoked by croton oil.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
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Edema / chemically induced
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Edema / drug therapy
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Glycosides
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Inflammation / chemically induced
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Inflammation / drug therapy
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Lonicera*
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Male
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Mice
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Mice, Inbred ICR
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Plant Components, Aerial
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / therapeutic use
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Saponins / chemistry
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Saponins / isolation & purification
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Saponins / therapeutic use*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Glycosides
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Plant Extracts
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Saponins
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loniceracetalide A