Abstract
One known (1) and two new cycloartane triglycosides, 20S,22R,23S,24R-16beta,23;22,25-diepoxy-cycloartane-3beta,23,24-triol 3-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranoside (2) and 20S,22R,23S,24R-16beta,23;22,25-diepoxy-cycloartane-3beta,23,24-triol 3-O-(6-O-trans-isoferuloyl-beta-D-glucopyranosyl)-(1-->2)-beta-D-glucopyranosyl-(1-->2)-beta-D-xylopyranoside (3), were isolated from a commercial Cimicifuga Rhizome. Their structures were determined by two dimensional (2D) NMR spectroscopic analysis and chemical evidence. These compounds suppressed the proliferation of lymphocytes in mouse allogeneic mixed lymphocyte reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cells, Cultured
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Cimicifuga*
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / isolation & purification
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Immunosuppressive Agents / pharmacology
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Lymphocyte Culture Test, Mixed / methods
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Male
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Rhizome*
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Triterpenes / chemistry*
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Triterpenes / isolation & purification
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Triterpenes / pharmacology
Substances
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Glycosides
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Immunosuppressive Agents
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Plant Extracts
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Triterpenes
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cycloartane