Abstract
The Gram-positive bacterium Streptococcus pyogenes is a major human pathogen causing substantial morbidity and mortality in society. S. pyogenes has evolved numerous molecular mechanisms to avoid the various actions of the human immune system and has established means to modulate both adaptive and innate immune responses. S. pyogenes produces and secretes proteolytic enzymes, which have an important impact on the ability of the bacteria to survive in the human host. Prominent among these are two immunoglobulin-degrading enzymes: the newly discovered streptococcal cysteine proteinase, IdeS, and the classical cysteine proteinase of S. pyogenes, SpeB.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibodies, Bacterial / metabolism*
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Bacterial Proteins / classification
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Bacterial Proteins / metabolism
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Cysteine Endopeptidases / classification
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Cysteine Endopeptidases / immunology
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Cysteine Endopeptidases / metabolism*
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Immunity, Innate
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Immunoglobulin Fc Fragments / immunology
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Immunoglobulin Fc Fragments / metabolism
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Immunoglobulin G / immunology
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Immunoglobulin G / metabolism
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Immunoglobulins / classification
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Immunoglobulins / metabolism*
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Streptococcus pyogenes / enzymology*
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Streptococcus pyogenes / pathogenicity
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Virulence
Substances
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Antibodies, Bacterial
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Bacterial Proteins
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Immunoglobulin Fc Fragments
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Immunoglobulin G
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Immunoglobulins
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Cysteine Endopeptidases
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streptopain