Abstract
We cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. The tinc mRNA was expressed specifically in four of the six pairs of cardioblasts in each segment, in a pattern identical to that of tinman (tin), a homeobox gene required for the specification of the dorsal vessel. In the non-Tin-expressing pairs of cardioblasts, tinc transcription seemed to be repressed by Seven-up.
Publication types
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Research Support, Non-U.S. Gov't
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Retracted Publication
MeSH terms
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Amino Acid Sequence
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Animals
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DNA-Binding Proteins / metabolism
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Drosophila / genetics*
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Drosophila / metabolism
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Drosophila Proteins / biosynthesis
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Drosophila Proteins / genetics*
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Gene Expression Regulation, Developmental
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In Situ Hybridization
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Membrane Proteins / biosynthesis
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Membrane Proteins / genetics*
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Molecular Sequence Data
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Myoblasts, Cardiac / metabolism*
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Receptors, Steroid / metabolism
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Repressor Proteins / biosynthesis
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Repressor Proteins / genetics*
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Trans-Activators / biosynthesis
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Trans-Activators / genetics*
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Membrane Proteins
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Receptors, Steroid
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Repressor Proteins
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Trans-Activators
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svp protein, Drosophila
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tin protein, Drosophila
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tinc protein, Drosophila