Abstract
This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide.
MeSH terms
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Apoptosis / drug effects
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Caspase Inhibitors
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Caspases / classification
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Cell Survival / drug effects
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Cells, Cultured
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Glycosylation
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Hydrogen Peroxide / chemistry
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Neurodegenerative Diseases / drug therapy
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Neurons / cytology
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / pharmacology
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Nitrogen Oxides / chemical synthesis*
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Nitrogen Oxides / chemistry
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Nitrogen Oxides / pharmacology*
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Oxidation-Reduction
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Spin Trapping
Substances
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Antioxidants
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Caspase Inhibitors
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Neuroprotective Agents
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Nitrogen Oxides
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nitrones
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Hydrogen Peroxide
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Caspases