Discovery of the first antibacterial small molecule inhibitors of MurB

Bioorg Med Chem Lett. 2003 Mar 10;13(5):873-5. doi: 10.1016/s0960-894x(02)01076-4.

Abstract

A series of imidazolinone analogues was synthesized and shown to possess potent MurB inhibitory as well as good antibacterial activity.

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology*
  • Carbohydrate Dehydrogenases / antagonists & inhibitors*
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Imidazoles / chemistry*
  • Imidazoles / pharmacology*
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • Anti-Bacterial Agents
  • Enzyme Inhibitors
  • Imidazoles
  • Carbohydrate Dehydrogenases
  • UDP-N-acetylmuramate dehydrogenase