Abstract
Seventy-two women diagnosed as parametritis were enrolled in this study and examined on the effective administration method of carbapenems, imipenem/cilastatin (IPM/CS), panipenem/betamipron (PAPM/BP) and meropenem (MEPM). The total dosage of each carbapenem was 1.5 g/day, and administration frequency was twice a day (0.75 g x 2) or three times a day (0.5 g x 3). We reviewed the highest body temperature, white blood cell count and CRP value, before treatment and the fourth day after the start of treatment. Three times a day method was statistically superior to twice a day method in the highest body temperature, and CRP value. When we use carbapenem antimicrobial agents, the basis of PK/PD of time above MIC would lead to the increasing clinical effects.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adult
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Aged
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Body Temperature
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C-Reactive Protein
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Carbapenems / administration & dosage*
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Carbapenems / pharmacokinetics
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Cilastatin / administration & dosage*
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Cilastatin / pharmacokinetics
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Cilastatin, Imipenem Drug Combination
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Drug Administration Schedule
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Drug Combinations
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Female
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Humans
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Imipenem / administration & dosage*
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Imipenem / pharmacokinetics
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Leukocyte Count
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Meropenem
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Middle Aged
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Parametritis / drug therapy*
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Parametritis / physiopathology
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Thienamycins / administration & dosage*
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Thienamycins / pharmacokinetics
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beta-Alanine / administration & dosage*
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beta-Alanine / analogs & derivatives
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beta-Alanine / pharmacokinetics
Substances
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Carbapenems
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Drug Combinations
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Thienamycins
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beta-Alanine
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panipenem-betamipron
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Cilastatin
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Imipenem
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C-Reactive Protein
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Cilastatin, Imipenem Drug Combination
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Meropenem