Abstract
With some defined conditions, electric pulses delivery to tissue in vivo can greatly enhance DNA transfection. We here describe the application in oncology of intratumoral or intramuscular DNA electrotransfer by using muscle as a secretory tissue of transgenic proteins displaying anticancer properties.
MeSH terms
-
Adenocarcinoma / enzymology
-
Adenocarcinoma / genetics
-
Adenocarcinoma / pathology
-
Adenocarcinoma / therapy
-
Animals
-
Carcinoma, Lewis Lung / enzymology
-
Carcinoma, Lewis Lung / genetics
-
Carcinoma, Lewis Lung / pathology
-
Carcinoma, Lewis Lung / therapy
-
Carcinoma, Non-Small-Cell Lung / enzymology
-
Carcinoma, Non-Small-Cell Lung / genetics
-
Carcinoma, Non-Small-Cell Lung / pathology
-
Carcinoma, Non-Small-Cell Lung / therapy
-
Colonic Neoplasms / enzymology
-
Colonic Neoplasms / genetics
-
Colonic Neoplasms / pathology
-
Colonic Neoplasms / therapy
-
DNA, Neoplasm / administration & dosage*
-
Electricity
-
Female
-
Fibrosarcoma / enzymology
-
Fibrosarcoma / genetics
-
Fibrosarcoma / pathology
-
Fibrosarcoma / therapy
-
Gene Transfer Techniques*
-
Genetic Therapy / methods
-
Humans
-
LLC-PK1 Cells
-
Luciferases / genetics
-
Lung Neoplasms / enzymology
-
Lung Neoplasms / genetics
-
Lung Neoplasms / pathology
-
Lung Neoplasms / therapy
-
Melanoma, Experimental / enzymology
-
Melanoma, Experimental / genetics
-
Melanoma, Experimental / pathology
-
Melanoma, Experimental / therapy
-
Mice
-
Mice, Inbred C57BL
-
Mice, Nude
-
Neoplasm Transplantation / methods
-
Plasmids / administration & dosage
-
Plasmids / genetics*
-
Tumor Cells, Cultured
Substances
-
DNA, Neoplasm
-
Luciferases