Spindle-cell tumours of the larynx: diagnostic pitfalls. A case report and review of the literature

Acta Otolaryngol. 2003 Jan;123(1):86-90. doi: 10.1080/0036554021000028070.

Abstract

Malignant laryngeal tumours with spindle-cell morphology are relatively rare. Differential diagnosis of spindle-cell carcinoma, leiomyosarcoma, fibrosarcoma, rhabdomyosarcoma, malignant melanoma and inflammatory myofibroblastic tumour may be particularly difficult. Ambiguous and indeterminate diagnoses are also possible after immunohistochemical investigations of the expression of specific tumour markers but electron microscopic observations help to clarify most of these diagnoses.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis
  • Carcinoma / pathology*
  • Carcinoma / radiotherapy
  • Carcinoma / surgery
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / radiotherapy
  • Carcinoma, Squamous Cell / surgery
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Humans
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / surgery
  • Laryngectomy
  • Larynx / pathology
  • Leiomyosarcoma / pathology*
  • Leiomyosarcoma / radiotherapy
  • Leiomyosarcoma / surgery
  • Male
  • Microscopy, Electron
  • Neoplasm Recurrence, Local / pathology*
  • Neoplasm Recurrence, Local / surgery
  • Reoperation

Substances

  • Biomarkers, Tumor