Abstract
The synthesis and biological activities of four pyochelin analogues substituted in different parts of the molecule are reported: 5-NHBoc-pyochelin, 3"N-Boc-pyochelin, 3"-nor-NH-pyochelin and neopyochelin II, the enantiomer of natural pyochelin. All these compounds complex iron(III) and transport it at different rates into the cells of Pseudomonas aeruginosa.
MeSH terms
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Indicators and Reagents
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Iron / metabolism
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Iron Chelating Agents / chemical synthesis*
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Iron Chelating Agents / pharmacology*
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Magnetic Resonance Spectroscopy
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Phenols / chemical synthesis*
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Phenols / pharmacology*
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Pseudomonas aeruginosa / chemistry*
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / metabolism
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Siderophores / chemical synthesis*
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Siderophores / pharmacology*
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Thiazoles*
Substances
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Indicators and Reagents
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Iron Chelating Agents
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Phenols
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Siderophores
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Thiazoles
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pyochelin
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Iron