Abstract
The synthesis and anti-angiogenic activities of linomide and its analogues are reported. Three of the analogues are 3.3-69 times more potent than linomide at inhibiting blood vessel formation in the CAM angiogenesis assay. These compounds possessed considerable anti-proliferative activity against isolated HUVEC cells with no activity against epithelial-derived prostate tumor cells.
MeSH terms
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Allantoin / chemistry
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / pharmacology*
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Animals
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Cell Division / drug effects
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Chick Embryo
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Endothelium, Vascular / cytology
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Endothelium, Vascular / drug effects
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Humans
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Hydroxyquinolines / chemical synthesis*
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Hydroxyquinolines / pharmacology*
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Male
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Membranes / drug effects
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / drug effects
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Prostatic Neoplasms / blood supply
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Prostatic Neoplasms / pathology
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Regional Blood Flow / drug effects
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Angiogenesis Inhibitors
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Hydroxyquinolines
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Allantoin
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roquinimex