Abstract
NF-kappa B comprises a family of transcription factors. These are thought to have a central role in the expression of genes involved in cell mobilization, cell proliferation and cell differentiation, and, hence, in inflammation, repair and fibrosis processes. In particular, NF-kappa B activation appears to drive a number of inflammatory diseases of the kidney and their progression to end-stage renal failure. Thus, targeting NF-kappa B activation would lead to the development of new pharmaceutical compounds that would provide novel treatment for these diseases.
MeSH terms
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Animals
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Anti-Inflammatory Agents / pharmacology
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Anti-Inflammatory Agents / therapeutic use
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Dimerization
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Disease Progression
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Fibrosis
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Gene Expression Regulation
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Glucocorticoids / pharmacology
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Glucocorticoids / therapeutic use
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Humans
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I-kappa B Proteins / metabolism
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I-kappa B Proteins / physiology
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Kidney / pathology*
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Kidney Failure, Chronic / etiology
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Kidney Failure, Chronic / prevention & control
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NF-KappaB Inhibitor alpha
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NF-kappa B / antagonists & inhibitors
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NF-kappa B / chemistry
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NF-kappa B / physiology*
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Nephritis / complications*
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Nephritis / drug therapy
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Nephritis / genetics
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Sclerosis
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Transcription, Genetic / drug effects
Substances
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Anti-Inflammatory Agents
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Glucocorticoids
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I-kappa B Proteins
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NF-kappa B
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NFKBIA protein, human
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NF-KappaB Inhibitor alpha