Abstract
Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.
MeSH terms
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Animals
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Antibodies, Bacterial / administration & dosage*
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Antibodies, Bacterial / therapeutic use
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Antibodies, Monoclonal / administration & dosage*
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Antibodies, Monoclonal / therapeutic use
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Antigens, Bacterial / immunology*
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Bacterial Proteins / immunology*
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Disease Models, Animal
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Drug Synergism
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Drug Therapy, Combination
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Humans
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Mice
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Mice, Inbred BALB C
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Plague / prevention & control*
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Plague / therapy*
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Pore Forming Cytotoxic Proteins
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Yersinia pestis / immunology*
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Yersinia pestis / pathogenicity
Substances
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Antibodies, Bacterial
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Antibodies, Monoclonal
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Antigens, Bacterial
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Bacterial Proteins
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LcrV protein, Yersinia
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Pore Forming Cytotoxic Proteins
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caf1 protein, Yersinia pestis