Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis

Petra J G Zwijnenburg; Tom van der Poll; Sandrine Florquin; John J Roord; A Marceline van Furth

doi:10.1128/IAI.71.4.2276-2279.2003

Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis

Infect Immun. 2003 Apr;71(4):2276-9. doi: 10.1128/IAI.71.4.2276-2279.2003.

Authors

Petra J G Zwijnenburg¹, Tom van der Poll, Sandrine Florquin, John J Roord, A Marceline van Furth

Affiliation

¹ Department of Pediatrics, Vrije Universiteit Medical Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. [email protected]

Abstract

To determine the role of endogenous interleukin-10 (IL-10) in local host defense during pneumococcal meningitis, the inflammatory responses of IL-10-gene-deficient and wild-type mice after the induction of meningitis were compared. The absence of IL-10 was associated with higher cytokine and chemokine concentrations and a more pronounced infiltrate, but antibacterial defense or survival was not influenced.

MeSH terms

Animals
Blood / microbiology
Brain / immunology
Brain / microbiology
Cerebrospinal Fluid / microbiology
Chemokines / metabolism*
Cytokines / metabolism*
Gene Expression Regulation*
Interleukin-10 / deficiency
Interleukin-10 / genetics
Interleukin-10 / immunology*
Meningitis, Pneumococcal / immunology*
Meningitis, Pneumococcal / microbiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Streptococcus pneumoniae / immunology
Streptococcus pneumoniae / pathogenicity*

Substances

Chemokines
Cytokines
Interleukin-10