Abstract
Siglecs are sialic-acid-binding proteins of the Ig superfamily that are involved in cell-cell interactions and signalling. In recent years, several novel siglecs that are highly related to CD33/Siglec-2 have been identified through genomics and functional screens. In addition to their distinct sialic-acid-binding properties, most of these novel siglecs bear tyrosine-based signalling motifs that are typically found in inhibitory receptors of the immune system. The restricted expression patterns of CD33-related siglecs in the haemopoietic and immune systems suggests that they are involved in regulating leucocyte activation during inflammatory and immune responses.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, CD / chemistry
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Antigens, CD / genetics*
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Antigens, CD / metabolism
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Antigens, Differentiation, Myelomonocytic / chemistry
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Antigens, Differentiation, Myelomonocytic / genetics*
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Antigens, Differentiation, Myelomonocytic / metabolism
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Evolution, Molecular
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Genomics*
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Humans
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Mice
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Molecular Sequence Data
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N-Acetylneuraminic Acid / metabolism
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Sequence Homology, Amino Acid
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Sialic Acid Binding Ig-like Lectin 3
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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CD33 protein, human
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Cd33 protein, mouse
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Sialic Acid Binding Ig-like Lectin 3
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N-Acetylneuraminic Acid