Membranous glomerulonephritis associated with follicular B-cell lymphoma and subepithelial deposition of IgG1-kappa paraprotein

Nephron Clin Pract. 2003;93(3):c112-8. doi: 10.1159/000069548.

Abstract

A case is described of B-cell lymphoma/chronic lymphocytic leukaemia associated with membranous glomerulonephritis in which the subepithelial deposits of immunoglobulin showed kappa light chain restriction by immunofluorescence. Surface IgG-kappa immunoglobulin was demonstrated on the malignant B cells, and a monoclonal protein of the same type was eluted from kidney. The mechanism of membranous glomerulonephritis in this type of lymphoid malignancy is clearly different from that in epithelial malignancies.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Fatal Outcome
  • Female
  • Glomerulonephritis, Membranous / diagnosis*
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulin G / metabolism*
  • Immunoglobulin G / ultrastructure
  • Immunoglobulin kappa-Chains / immunology
  • Immunoglobulin kappa-Chains / metabolism*
  • Immunoglobulin kappa-Chains / ultrastructure
  • Immunohistochemistry
  • Kidney Glomerulus / chemistry
  • Kidney Glomerulus / pathology
  • Kidney Glomerulus / ultrastructure
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Lymphoma, B-Cell / pathology*
  • Lymphoma, Follicular / pathology*
  • Paraproteins / immunology
  • Paraproteins / metabolism*
  • Paraproteins / ultrastructure
  • Pulmonary Embolism / pathology

Substances

  • Immunoglobulin G
  • Immunoglobulin kappa-Chains
  • Paraproteins