Inhibition of 5-LO activating protein (FLAP) activity decreases proteinuria in streptozotocin (STZ)-induced diabetic rats

Adv Exp Med Biol. 2002:507:79-83. doi: 10.1007/978-1-4615-0193-0_13.
No abstract available

MeSH terms

  • 5-Lipoxygenase-Activating Proteins
  • Animals
  • Blood Glucose / metabolism
  • Blood Urea Nitrogen
  • Carrier Proteins / antagonists & inhibitors*
  • Diabetes Mellitus, Experimental / urine*
  • Diabetic Nephropathies / prevention & control
  • Diuresis / drug effects
  • Hydroxyurea / analogs & derivatives*
  • Hydroxyurea / therapeutic use*
  • Lipoxygenase Inhibitors / therapeutic use*
  • Male
  • Membrane Proteins / antagonists & inhibitors*
  • Proteinuria / prevention & control*
  • Quinolines / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley

Substances

  • 5-Lipoxygenase-Activating Proteins
  • Blood Glucose
  • Carrier Proteins
  • Lipoxygenase Inhibitors
  • Membrane Proteins
  • Quinolines
  • 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid
  • zileuton
  • Hydroxyurea