Abstract
Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Aged
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Carrier Proteins / metabolism
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Cholinergic Fibers / metabolism
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Corpus Striatum / cytology
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Corpus Striatum / diagnostic imaging*
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Female
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Humans
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Iodine Radioisotopes
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Male
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Membrane Transport Proteins*
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Middle Aged
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Piperidines
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Tetrahydronaphthalenes
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Tomography, Emission-Computed, Single-Photon*
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Torticollis / diagnostic imaging*
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Torticollis / metabolism*
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Vesicular Acetylcholine Transport Proteins
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Vesicular Transport Proteins*
Substances
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Carrier Proteins
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Iodine Radioisotopes
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Membrane Transport Proteins
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Piperidines
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SLC18A3 protein, human
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Tetrahydronaphthalenes
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Vesicular Acetylcholine Transport Proteins
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Vesicular Transport Proteins
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5-iodobenzovesamicol