Effects of a series of dihydroanthracene derivatives on drug efflux in multidrug resistant cancer cells

Eur J Med Chem. 2003 Mar;38(3):253-63. doi: 10.1016/s0223-5234(03)00018-7.

Abstract

A set of 9,10-dihydro-9,10-ethano and ethenoanthracene derivatives was tested with the aim to quantify the effect observed on drug efflux. Structure activity relationships and molecular modeling studies allowed to define topological display of pharmacophoric groups for these reversal agents.

MeSH terms

  • Animals
  • Anthracenes / chemical synthesis*
  • Anthracenes / pharmacology*
  • Cell Line, Tumor
  • Chromatography, Thin Layer
  • Computational Biology
  • Drug Resistance, Multiple / physiology*
  • Drug Resistance, Neoplasm / physiology*
  • Fluorescent Dyes
  • Hydrogen Bonding
  • Indicators and Reagents
  • Mice
  • Models, Molecular
  • Pharmaceutical Preparations / metabolism*
  • Propafenone / chemistry
  • Quantitative Structure-Activity Relationship
  • Rhodamine 123

Substances

  • Anthracenes
  • Fluorescent Dyes
  • Indicators and Reagents
  • Pharmaceutical Preparations
  • Rhodamine 123
  • Propafenone