Macrocyclic inhibitors of the NS3 protease as potential therapeutic agents of hepatitis C virus infection

Angew Chem Int Ed Engl. 2003 Mar 28;42(12):1356-60. doi: 10.1002/anie.200390347.
No abstract available

MeSH terms

  • Amino Acid Sequence
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology*
  • Binding Sites
  • Carcinoma, Hepatocellular
  • Hepacivirus / drug effects
  • Hepacivirus / enzymology*
  • Humans
  • Inhibitory Concentration 50
  • Liver / cytology
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology*
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured
  • Viral Nonstructural Proteins / antagonists & inhibitors*

Substances

  • Antiviral Agents
  • NS3 protein, hepatitis C virus
  • Peptides, Cyclic
  • Protease Inhibitors
  • Viral Nonstructural Proteins