Successful treatment of subcutaneously disseminated aspergillosis with caspofungin acetate in an allogeneic peripheral blood stem cell transplantation patient

M E D Chamuleau; W Deenik; S Zweegman; A R Jonkhoff; H L Zaaijer; J J W M Janssen

Successful treatment of subcutaneously disseminated aspergillosis with caspofungin acetate in an allogeneic peripheral blood stem cell transplantation patient

Haematologica. 2003 Apr;88(4):ECR10.

Authors

M E D Chamuleau¹, W Deenik, S Zweegman, A R Jonkhoff, H L Zaaijer, J J W M Janssen

Affiliation

¹ Department of Haematology, VU University Medical Centre De Boelelaan, Amsterdam, The Netherlands.

PMID: 12681983

Abstract

We present a patient with acute myeloid leukaemia who developed subcutaneously disseminated aspergillosis after allogeneic peripheral stem cell transplantation (PSCT). Disseminated aspergillosis after stem cell transplantation has a high mortality despite treatment with amphotericin B or one of the azoles. Aspergillosis in our patient was refractory to amphotericin B and itraconazole but was successfully treated with caspofungin acetate.

Publication types

Case Reports

MeSH terms

Antifungal Agents / therapeutic use
Aspergillosis / drug therapy*
Aspergillosis / etiology
Caspofungin
Drug Resistance
Echinocandins
Female
Humans
Leukemia, Myeloid / complications
Leukemia, Myeloid / therapy
Lipopeptides
Middle Aged
Peptides / therapeutic use*
Peptides, Cyclic*
Peripheral Blood Stem Cell Transplantation / adverse effects*
Transplantation, Homologous
Treatment Outcome

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides
Peptides, Cyclic
Caspofungin