Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly

Circulation. 2003 Apr 22;107(15):2021-4. doi: 10.1161/01.CIR.0000065231.07729.92. Epub 2003 Apr 7.

Abstract

Background: Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.

Methods and results: A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the beta2-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of beta2-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.

Conclusions: The Glu27 allele of the beta2-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alleles
  • Black People / genetics*
  • Black or African American
  • Brain Ischemia / epidemiology
  • Brain Ischemia / genetics
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / genetics*
  • Cohort Studies
  • Comorbidity
  • Coronary Disease / epidemiology
  • Coronary Disease / genetics
  • Follow-Up Studies
  • Gene Frequency
  • Humans
  • Incidence
  • Linkage Disequilibrium
  • Polymorphism, Genetic*
  • Receptors, Adrenergic, beta-2 / genetics*
  • Risk Assessment
  • Stroke / epidemiology
  • Stroke / genetics
  • United States / epidemiology
  • White People / genetics*

Substances

  • Receptors, Adrenergic, beta-2