Distinctiveness of Mycobacterium tuberculosis genotypes from human immunodeficiency virus type 1-seropositive and -seronegative patients in Lima, Peru

J Clin Microbiol. 2003 Apr;41(4):1712-6. doi: 10.1128/JCM.41.4.1712-1716.2003.

Abstract

Genotypic analysis of Mycobacterium tuberculosis isolates obtained from human immunodeficiency virus type 1 (HIV-1)-seropositive (n = 80) and -seronegative (n = 25) patients from Lima, Peru, revealed two distinct genotypes correlating with the host immune status. While the level of intrastrain diversity of DNA fingerprints of HIV-seropositive isolates was less pronounced, these isolates showed many clonal groupings.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / microbiology
  • DNA Fingerprinting / methods
  • Genotype
  • HIV Seronegativity*
  • HIV Seropositivity / complications*
  • Humans
  • Mycobacterium tuberculosis / classification*
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Peru
  • Phylogeny
  • Polymorphism, Restriction Fragment Length
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / microbiology*