Cerebral venous thrombosis: clinical outcome and systematic screening of prothrombotic factors

Neurology. 2003 Apr 8;60(7):1175-8. doi: 10.1212/01.wnl.0000055811.05743.10.

Abstract

The authors studied 16 consecutive cases of cerebral venous thrombosis (CVT). Clinical outcome was good or excellent in 14 patients. Comprehensive hypercoagulable screening was done at least 3 months after the onset of CVT, including evaluation of genetic coagulation disorders and plasma levels of homocysteine and factor VIII. This screening was positive in 12 patients (75%). An acquired prothrombotic factor was identified in 9 of these 12 patients. Elevation of factor VIII plasma level was the most common coagulation disorder (8 patients).

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Anticoagulants / therapeutic use
  • Cerebral Angiography
  • Disability Evaluation
  • Factor VIII / analysis
  • Female
  • Heparin / therapeutic use
  • Homocysteine / blood
  • Humans
  • Intracranial Thrombosis / diagnosis*
  • Intracranial Thrombosis / etiology*
  • Intracranial Thrombosis / therapy
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Male
  • Mass Screening
  • Thrombophilia / complications*
  • Thrombophilia / diagnosis*
  • Thrombophilia / drug therapy
  • Time Factors
  • Treatment Outcome

Substances

  • Anticoagulants
  • Homocysteine
  • Factor VIII
  • Heparin