Abstract
Recently, much interest have been focused on the role of INI-1, a partner gene of transfusion protein All-1 for leukemogenesis of acute leukemia cases. We found the presence of a mutation at codon 152 in INI-1 that resulted in a conservative amino acid change in cDNA and genomic DNA from an AML patient. We also found the known polymorphic nucleotide change at the third letter of codon 299 in exon 7 of INI-1 in 3 of 31 ALL cases and in 4 of 30 AML cases. In conclusion, INI-1, a partner gene for ALL-1, is considered to be highly conserved in acute leukemia cases.
MeSH terms
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Chromosomal Proteins, Non-Histone
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Codon
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Conserved Sequence / genetics*
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DNA Primers / chemistry
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DNA, Complementary
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DNA, Neoplasm / genetics
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DNA, Neoplasm / metabolism
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DNA-Binding Proteins / genetics*
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Exons / genetics
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Gene Rearrangement
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Histone-Lysine N-Methyltransferase
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Humans
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Leukemia, Myeloid, Acute / genetics*
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Mutation / genetics*
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Myeloid-Lymphoid Leukemia Protein
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Polymerase Chain Reaction
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Polymorphism, Genetic
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
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Proto-Oncogenes*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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RNA, Neoplasm / genetics
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RNA, Neoplasm / metabolism
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SMARCB1 Protein
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Transcription Factors*
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Tumor Cells, Cultured
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Zinc Fingers
Substances
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Chromosomal Proteins, Non-Histone
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Codon
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DNA Primers
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DNA, Complementary
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DNA, Neoplasm
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DNA-Binding Proteins
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KMT2A protein, human
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RNA, Messenger
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RNA, Neoplasm
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SMARCB1 Protein
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SMARCB1 protein, human
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Transcription Factors
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Myeloid-Lymphoid Leukemia Protein
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Histone-Lysine N-Methyltransferase